Domperidone Breast Milk Supply

Domperidone is an antiemetic (anti-sickness) and prokinetic drug. It belongs to a group of drugs called dopamine antagonists. It is used to treat stomach-related issues, such as nausea and vomiting, as well as stomach pain and discomfort caused by decreased movement of the stomach and upper gastrointestinal (GI) tract. It is also used to boost breastmilk supply.

Domperidone works by blocking dopamine receptors in the gut. It increases the movement or contractions of the muscles in your stomach and intestines, increasing how quickly and easily food moves through your digestive tract. It also acts on the chemoreceptor trigger zone in your brain, which is involved in nausea and vomiting. This area of your brain is outside the blood-brain barrier. Unlike other dopamine antagonists, domperidone does not cross the blood-brain barrier, which minimizes central nervous system (CNS) side effects.

Domperidone is used for a range of conditions including:

• To treat nausea (feeling sick) and vomiting (being sick), including when it is caused by migraine headaches
• To prevent nausea and vomiting caused by certain medicines used to treat Parkinson’s disease, including levodopa and pergolide
• To relieve discomfort caused by a slow moving stomach known as gastroparesis. Symptoms include indigestion (dyspepsia), not being able to finish a meal, feeling too full or bloated after a meal, a loss of appetite, feeling sick and maybe vomiting, or belching without relief
• To increase breastmilk supply